Reinhart Jarisch

  • Designation: FAZ, Floridsdorf Allergy Center, Vienna
  • Country: Austria
  • Title: Post Infectious Spermidine Levels Remain Reduced Over a Prolonged Time Period After Viral Infections


Reinhart Jarisch, FAZ, Floridsdorf Allergy Center, Vienna, Austria. He successfully studied seasickness with the German navy and Successfully treated dementia with spermidine. He established antihistamine premedication.


Post-infectious diseases such as Long-COVID and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) affect millions of patients and represent a worldwide healthcare problem. Currently, there is no biomarker for the diagnosis, and due to the lack of knowledge about disease mechanisms, no causative treatment is available. Upon infection, SARS-CoV-2 is known to modulate cellular metabolism and reduce autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. Spermidine is known to enhance autophagy in brain tissue. Of interest is that spermidine, given to a culture of coronaviruses, can inhibit the release of infectious SARS-CoV-2 particles by 87%. We, therefore, speculated that a low spermidine level could be a typical laboratory marker for post-viral ME/CFS and long-term COVID patients.
Material and methods: We measured spermidine levels in serum samples from patients who developed ME/CFS after EBV infection (n=16), Long COVID patients (n=30), patients who fully recovered after SARS-CoV-2 infections (n=30) and compared the results with healthy persons (n=30). Spermidine levels were measured using the ELISA- Kit from abbexa®.
Results: We measured significantly reduced spermidine levels in samples from patients fully recovered after SARS-CoV-2 infections compared to healthy controls. Samples from this group were collected in a median of 119 days after infection. Our data indicate a long-term impact of viral infections on systemic spermidine levels.
Discussion: As the biogenic amine spermidine is mandatory for normal brain function, reduced sperminide levels might impact the development of post-viral disease.

Don't miss our future updates!

Get in Touch