Dubai
3rd Edition of Dementia World Conference (DWC) 2026
Speakers - DWC 2025
Mohammed Din
- Designation: Anglia Ruskin University
- Country: UK
- Title: Can tear biomarkers be used to diagnose Alzheimers Disease
Abstract
Alzheimer’s disease (AD) , the leading cause of dementia, is an age-related neurodegenerative disorder characterised by the accumulation of amyloid-beta peptides and tau proteins in the brain . Though under-investigated , tears fluid offers a cost-effective , minimally invasive alternative for early detection of AD , reflecting the systemic changes and biochemical footprint left behind by neurodegenerative processes waiting to be explored .This systematic review examines the presence of tear biomarkers and compares their concentrations among healthy individuals, those with mild cognitive impairment (MCI), and AD patients. The results revealed certain biomarkers, such as dermicidin and MicroRNA-200b-5p , show high sensitivity and specificity for AD. Furthermore, AD patients showed an increase in tear flow rate and overall tear protein concentrations. The findings of this study may serve as a catalyst to redirect research attention towards the viability of tears as a candidate for AD diagnosis , with our research suggesting them to be a promising reservoir for early detection of AD and future biomarker discovery.
Dementia, Alzheimer, and Parkinson's Disease: 3rd Edition of Dementia World Conference (DWC) 2026: Redisco ...
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